UNIT 1: PROTEIN STRUCTURE AND FUNCTION (Chapters 1-4)

ASSIGNMENT NO. 1: WHAT IS THE IMPORTANCE OF BIOCHEMISTRY IN PHARMACY?

Minimum: 500 words, Maximum: 1200 words. Submission Date: 01 February 2010 in class

Typed using Times New Romans, Font size 12pt and Line spacing of 1.

On top of first page mention the Surname & Initials, Student Number, Course Code, Assignment One: What is the importance of Biochemistry in Pharmacy? … and then start with your assignment(don’t make a traditional cover page with your personal details, just go on and write)

Proteins are very important molecules in our cells. They are involved in virtually all cell functions. Each protein within the body has a specific function. Some proteins are involved in structural support, while others are involved in bodily movement, or in defense against germs. Proteins vary in structure as well as function. They are constructed from a set of 20 amino acids and have distinct three-dimensional shapes. Below is a list of several types of proteins and their functions.

Protein Functions

1. Antibodies - are specialized proteins involved in defending the body from antigens (foreign invaders). One way antibodies destroy antigens is by immobilizing them so that they can be destroyed by white blood cells.

2. Contractile Proteins - are responsible for movement. Examples include actin and myosin. These proteins are involved in muscle contraction and movement.

3. Enzymes - are proteins that facilitate biochemical reactions. They are often referred to as catalysts because they speed up chemical reactions. Examples include the enzymes lactase and pepsin. Lactase breaks down the sugar lactose found in milk. Pepsin is a digestive enzyme that works in the stomach to break down proteins in food.

4. Hormonal Proteins - are messenger proteins which help to coordinate certain bodily activities. Examples include insulin, oxytocin, and somatotropin. Insulin regulates glucose metabolism by controlling the blood-sugar concentration. Oxytocin stimulates contractions in females during childbirth. Somatotropin is a growth hormone that stimulates protein production in muscle cells.

5. Structural Proteins - are fibrous and stringy and provide support. Examples include keratin, collagen, and elastin. Keratins strengthen protective coverings such as hair, quills, feathers, horns, and beaks. Collagens and elastin provide support for connective tissues such as tendons and ligaments.

6. Storage Proteins - store amino acids. Examples include ovalbumin and casein. Ovalbumin is found in egg whites and casein is a milk-based protein.

7. Transport Proteins - are carrier proteins which move molecules from one place to another around the body. Examples include hemoglobin and cytochromes. Hemoglobin transports oxygen through the blood. Cytochromes operate in the electron transport chain as electron carrier proteins.

Summary: Proteins serve various functions in the body. The structure of a protein determines its function. For example, collagen has a super-coiled helical shape. It is long, stringy, strong, and resembles a rope. This structure is great for providing support. Hemoglobin on the other hand, is a globular protein that is folded and compact. Its spherical shape is useful for maneuvering through blood vessels.